BDBM207629 US9265734, R01::US9796664, Compound R01

SMILES Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N

InChI Key InChIKey=VOPDXHFYDJAYNS-UHFFFAOYSA-N

Data  3 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 207629   

TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  5nMAssay Description:Binding affinity to human recombinant HDAC3 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50:  300nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50:  60nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant full length human HDAC3 expressed in insect Sf9 cells at 10 uM measured after 1 hr by EMSA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50:  300nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In DepthDetails US Patent